Immunohistochemical analysis of marker expression was performed on tissue samples from 25 patients with tongue squamous cell carcinoma. An integrated approach for identification of a panel of candidate genes arbitrated for invasion and metastasis in oral squamous cell carcinoma. 2021 Feb 16;9(2):194. doi: 10.3390/biomedicines9020194. Head Neck. Prognostic Significance of Cytoplasmic SPNS2 Expression in Patients with Oral Squamous Cell Carcinoma. Virchows Arch 467(1): 39–46. 15 , 2277–2286 (2019). For several decades the management of OSCC consisted of surgery with or without radiotherapy or chemoradiotherapy. CAS Article Google Scholar Meta-analysis of immunohistochemical prognostic markers in resected pancreatic cancer. Careers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. Oral Oncol 48(12): 1263–1271. National Library of Medicine For the five most often evaluated biomarkers a random-effects meta-analysis on overall survival was performed, including those studies that provided the necessary statistical results. FOIA Routray S, Kumar R, Datta KK, Puttamallesh VN, Chatterjee A, Gowda H, Mohanty N, Dash R, Dixit A. Sci Rep. 2021 Mar 18;11(1):6208. doi: 10.1038/s41598-021-85729-x. Prevention and treatment information (HHS). GLUT1 and GLUT3 protein expression evaluated by immunohistochemistry are, significantly, indicators of poor prognosis outcome in oral squamous cell carcinoma, probably due to the enhanced glycolytic metabolism of more aggressive neoplastic cells. doi: 10.1038/bjc.2017.491. Epub 2019 Feb 27. MicroRNA expression patterns in oral squamous cell carcinoma: hsa‐mir‐99b‐3p and hsa‐mir‐100‐5p as novel prognostic markers for oral cancer. Introduction. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies. Prevention and treatment information (HHS). MicroRNAs as Important Players and Biomarkers in Oral Carcinogenesis. Unable to load your collection due to an error, Unable to load your delegates due to an error. Bethesda, MD 20894, Copyright Epub 2015 Oct 4. 10.1038/s41416-019-0409-6 [Europe PMC free article] [Google Scholar] Front Public Health. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2013 Feb;18(1):154-63. doi: 10.1007/s10147-011-0358-4. The systemic inflammatory response and nutritional status of patients with malignant tumors are related to postoperative results. Si Q, Ye Q, Bing Z, Fan R, Hu X, Liu B, Wang J, Liu Y, An X. Predictive Prognostic Value of Tissue-Based MicroRNA Expression in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-analysis. 1. A total of 174 studies conducted during the last three decades were found, and in these 184 biomarkers were evaluated for the prognostication of OTSCC. The authors declare no conflict of interest. Oral squamous cell carcinoma (OSCC) is the major cancer of head and neck with increasing incidence and mortality in Taiwan. 2019 Apr;120(7):714-727. doi: 10.1038/s41416-019-0409-6. Bova RJ, Quinn DI, Nankervis JS, Cole IE, Sheridan BF, Jensen MJ, Morgan GJ, Hughes CJ, Sutherland RL. This site needs JavaScript to work properly. The selected studies are of good quality, although, any study referred to a sample size determination. eCollection 2021. A systematic search of the literature was performed using the databases of Scopus, Ovid Medline, Web of Science and Cochrane Library. Methods: Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and … Results: The five biomarkers most frequently assessed were p53, Ki-67, p16, VEGFs and cyclin D1. Carbon Ion Irradiation Enhances the Anti-tumor Efficiency in Tongue Squamous Cell Carcinoma via Modulating the FAK Signaling. Mark Jakob MD. Would you like email updates of new search results? For studies of VEGF A and C the results were equivocal, but the pooled analysis of VEGF A separately showed it to be a useful prognosticator for OTSCC. Immunohistochemistry panels are used to evaluate proliferation, vascularization, apoptosis, HPV infection, and keratin expression, which are important markers of malignant progression. BMC Med 10: 51. We investigate hnRNP K, TP and FLIP expression and assess the prognostic and therapeutic potential of these markers in oral squamous cell carcinoma (OSCC). Glut1 and Glut3 as Potential Prognostic Markers for Oral Squamous Cell Carcinoma Fernanda Rocha Rojas Ayala , 1 Rafael Malagoli Rocha , 1, * Kátia Cândido Carvalho , 1 André Lopes Carvalho , 2, 3 Isabela Werneck da Cunha , 1 Silvia Vanessa Lourenço , 4 and Fernando Augusto Soares 1 An integrated approach for identification of a panel of candidate genes arbitrated for invasion and metastasis in oral squamous cell carcinoma. 2016 Sep 1;142(9):857-65. doi: 10.1001/jamaoto.2016.1281. PLoS Med 9(5): e1001216. Methods: A systematic search of the literature was performed using the databases of … In this study, we identify the levels of iNOS and nitrotyrosine in the sample of normal oral mucosa (NOM), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Elective Neck Dissection vs Observation in Early-Stage Squamous Cell Carcinoma of the Oral Tongue With No Clinically Apparent Lymph Node Metastasis in the Neck: A Systematic Review and Meta-analysis. The overall 5-year survival rate following treatment for oral squamous cell carcinoma is around 50% in most published series. Epub 2011 Dec 15. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Epub 2011 Mar 29. 1. 2021 Mar 4;11:545433. doi: 10.3389/fonc.2021.545433. Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. 2021 Feb 1;39(1):64-73. doi: 10.7518/hxkq.2021.01.010. We examined the usefulness of the prognostic nutritional index (PNI) as a prognostic tool in patients with oral squamous cell carcinoma who underwent radical surgery. Numerous biomarkers have been presented as useful prognosticators for OTSCC, but the quality of the conduct and reporting of original studies is overall unsatisfactory which does not allow reliable conclusions. Peer J 8:e9393 DOI 10.7717/peerj.9393 Epub 2019 Jul 29. We included primary articlesreporting overall survival, disease-free survival and cause-specific survival as outcomes. Zedan W(1), Mourad MI(2), El-Aziz SM(3), Salamaa NM(4), Shalaby AA(5). 2019 Jan;152(1):208-217. doi: 10.1016/j.ygyno.2018.10.015. The major prognostic factors are stage at the time of diagnosis, unexpected close margins at resection, depth and pattern of tissue invasion by carcinoma and extracapsular spread. Preoperative high c-reactive protein/albumin ratio is a poor prognostic factor of oral squamous cell carcinoma. Would you like email updates of new search results? Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis Br J Cancer . 8600 Rockville Pike Identification of inflammatory mediators associated with metastasis of oral squamous cell carcinoma in experimental and clinical studies: systematic review. Cyclin D1 and p16INK4A expression predict reduced survival in carcinoma of the anterior tongue. 8600 Rockville Pike Conclusions: Importance of the PD-1/PD-L1 Axis for Malignant Transformation and Risk Assessment of Oral Leukoplakia. Five-year survival rates for oral squamous cell carcinoma (OSCC) are 30% and the mortality rate is 50%. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Wang SR, Sun W, Zhou N, Zhao K, Li WJ, Chi ZP, Wang Y, Wang QM, Tong L, He ZX, Han HY, Chen ZG. 1544 - 1556 CrossRef View Record in Scopus Google Scholar Silva Servato JP(1), Ueira Vieira C(2), de Faria PR(3), Cardoso SV(4), Loyola AM(4). Medicina (Kaunas). -. as a novel diagnostic/prognostic biomarker for oral squamous cell carcinoma via RNA sequencing and bioinformatic analyses. Tumour budding in oral squamous cell carcinoma: a meta-analysis. 2021 Mar 8;11:616629. doi: 10.3389/fonc.2021.616629. Methods Quantitative polymerase chain reactions (qPCRs) were utilized to detect the NOS2 levels in fresh‐frozen tissue samples of NOM (n = 6), OL (n = 20), and OSCC (n = 15). Eligible studies were identified through a literature s … Therefore, the aim of the present study was to evaluate the prognostic impact of eight miRNAs connected to oral squamous cell carcinoma (OSCC). eCollection 2021. 2011 Apr 26;104(9):1440-51. doi: 10.1038/bjc.2011.110. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC. Li P, Fang Q, Yang Y, Chen D, Du W, Liu F, Luo R. Front Oncol. Smith RA, Tang J, Tudur-Smith C, Neoptolemos JP, Ghaneh P. Br J Cancer. -, Altman DG, McShane LM, Sauerbrei W, Taube SE (2012. a) Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration. Gynecol Oncol. Limitations in the quality of the published studies (e.g., small cohorts, lack of compliance with REMARK guidelines) are widespread. Sci Rep. 2021 Mar 25;11(1):6939. doi: 10.1038/s41598-021-86208-z. Careers. Oral squamous cell carcinoma (OSCC) has always been one of the most aggressive and invasive cancers among oral and maxillofacial malignancies. The objective of the study was to examine the prognostic value of hypoxia-inducible factor-1α (HIF-1α), carbonic anhydrase-IX (CA-IX), cyclooxygenase-2 (COX-2), Ki-67, and erythropoietin receptor in patients with oral tongue squamous cell carcinoma. 2019 Nov 25;33:e103. Barnabé LÉG, Batista AC, Mendonça EF, Nonaka CFW, Alves PM. 2015;2015:186904. doi: 10.1155/2015/186904. -, Almangush A, Bello IO, Coletta RD, Makitie AA, Makinen LK, Kauppila JH, Pukkila M, Hagstrom J, Laranne J, Soini Y, Kosma VM, Koivunen P, Kelner N, Kowalski LP, Grenman R, Leivo I, Läärä E, Salo T (2015) For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality. Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis. Privacy, Help 2019 Oct;41(10):3499-3515. doi: 10.1002/hed.25866. Routray S, Kumar R, Datta KK, Puttamallesh VN, Chatterjee A, Gowda H, Mohanty N, Dash R, Dixit A. Sci Rep. 2021 Mar 18;11(1):6208. doi: 10.1038/s41598-021-85729-x. The value of two biomarkers (VEGF-A and cyclin D1) should be validated in a multicentre study setting following REMARK guidelines. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC. eCollection 2019. 2021 Feb 12;57(2):164. doi: 10.3390/medicina57020164. Oral squamous cell carcinoma (OSCC) is one of the most common types of malignancies worldwide, and its morbidity and mortality have increased in the near term. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Clipboard, Search History, and several other advanced features are temporarily unavailable. Privacy, Help Kiyosue T, Kawano S, Matsubara R, Goto Y, Hirano M, Jinno T, Toyoshima T, Kitamura R, Oobu K, Nakamura S. Int J Clin Oncol. doi: 10.1038/bjc.2017.482. Epub 2019 Sep 26. Aiming to increase survival rate, recent research has underlined the significance of harnessing the immune response in treatment of many cancers. Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'. doi: 10.1590/1807-3107bor-2019.vol33.0103. The prognostic value of p16 and p53 expression for survival after vulvar cancer: A systematic review and meta-analysis. Over 260,000 (2013) new oral squamous cell carcinoma (OSCC) cases are reported annually worldwide. Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a … Sand FL, Nielsen DMB, Frederiksen MH, Rasmussen CL, Kjaer SK. [Epub ahead of print] The importance of inducible nitric oxide synthase and nitrotyrosine as prognostic markers for oral squamous cell carcinoma. Min A, Zhu C, Peng S, Rajthala S, Costea DE, Sapkota D. Biomed Res Int. Br J Cancer. Background: Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Front Oncol. FOIA 2019 Aug 4. doi: 10.1111/jop.12942. 2019 Dec;36(6):481-492. doi: 10.1007/s10585-019-09994-x. Epub 2017 Nov 30. This site needs JavaScript to work properly. All studies which had investigated the prognostic significance of immunohistochemical biomarkers in OTSCC during the period from 1985 to 2015 were retrieved. 2018 Mar 6;118(5):e11. NCI CPTC Antibody Characterization Program, Adduri R Sr, Kotapalli V, Gupta NA, Gowrishankar S, Srinivasulu M, Ali MM, Rao S, Uppin SG, Nayak UK, Dhagam S, Chigurupati MV, Bashyam MD (2014) P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue. Almangush A, Heikkinen I, Mäkitie AA, Coletta RD, Läärä E, Leivo I, Salo T. Br J Cancer. Elhousiny M, Miller K, Ariyawadana A, Nimmo A. Clin Exp Metastasis. Abu-Ghanem S, Yehuda M, Carmel NN, Leshno M, Abergel A, Gutfeld O, Fliss DM. eCollection 2021. Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Please enable it to take advantage of the complete set of features! 2018 Mar 6;118(5):e12. Lu JW, Tseng YS, Lo YS, Lin YM, Yeh CM, Lin SH. Survival Significance of Number of Positive Lymph Nodes in Oral Squamous Cell Carcinoma Stratified by p16. -, Altman DG, McShane LM, Sauerbrei W, Taube SE (2012. b) Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration. BMC Clin Pathol 14: 37. Cell cycle markers and apoptotic proteins in oral tongue squamous cell carcinoma in young and elderly patients. COVID-19 is an emerging, rapidly evolving situation. Future Oncol. Accessibility Cytogenetic significance of chromosome 17 aberrations and P53 gene mutations as prognostic markers in oral squamous cell carcinoma. Oral cavity squamous cell carcinoma (OSCC) is the most common cancer of the head and neck and accounts for approximately 3% of all newly diagnosed cancer cases , , .Despite recent advances in surgical, radiotherapy, and chemotherapy treatment protocols, the long-term survival of patients with OSCC still lacks significant improvement for the past three decades. eCollection 2021. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. Biomarkers for Immunotherapy of Oral Squamous Cell Carcinoma: Current Status and Challenges. Biomarkers for Immunotherapy of Oral Squamous Cell Carcinoma: Current Status and Challenges. Bethesda, MD 20894, Copyright 2021 Mar 8;11:616629. doi: 10.3389/fonc.2021.616629. Epub 2018 Feb 15. COVID-19 is an emerging, rapidly evolving situation. Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. 2021 Feb 3;9:631118. doi: 10.3389/fpubh.2021.631118. Copyright © 2017 Elsevier Ltd. All rights reserved. MicroRNA expression patterns in oral squamous cell carcinoma: hsa-mir-99b-3p and hsa-mir-100-5p as novel prognostic markers for oral cancer. Accessibility Despite development in OSCC management, the outcome is still unsatisfactory. Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis". Hua Xi Kou Qiang Yi Xue Za Zhi. In the meta-analyses, the most promising results of the prognostic power for OTSCC were obtained for cyclin D1. Background: There was no sufficient evidence to support p53, Ki-67 and p16 as prognostic biomarkers for OTSCC. Almangush A, Pirinen M, Heikkinen I, Mäkitie AA, Salo T, Leivo I. Br J Cancer. Front Oncol. SPINK7 expression changes accompanied by HER2, P53 and RB1 can be relevant in predicting oral squamous cell carcinoma at a molecular level. As the morbidity and mortality of the disease have increased year by year, the search for a promising diagnostic and prognostic biomarker for the disease is becoming increasingly urgent. Oral squamous cell carcinoma (OSCC) forms a major health problem in many countries. 2018 Jul;97(7):759-766. doi: 10.1177/0022034518762090. Hadler-Olsen, E., Wirsing, A.M. Tissue-infiltrating immune cells as prognostic markers in oral squamous cell carcinoma: a systematic review and meta-analysis. -, Albert S, Hourseau M, Halimi C, Serova M, Descatoire V, Barry B, Couvelard A, Riveiro ME, Tijeras-Raballand A, de Gramont A, Raymond E, Faivre S (2012) Prognostic value of the chemokine receptor CXCR4 and epithelial-to-mesenchymal transition in patients with squamous cell carcinoma of the mobile tongue. Please enable it to take advantage of the complete set of features! Tumorous and adjacent tissues were collected from three … Unable to load your collection due to an error, Unable to load your delegates due to an error. 2019 Apr;120(7):714-727. doi: 10.1038/s41416-019-0409-6. 1. Troiano G, Mastrangelo F, Caponio VCA, Laino L, Cirillo N, Lo Muzio L. J Dent Res. Pennacchiotti G, Valdés-Gutiérrez F, González-Arriagada WA, Montes HF, Parra JMR, Guida VA, Gómez SE, Guerrero-Gimenez ME, Fernandez-Muñoz JM, Zoppino FCM, Carón RW, Ezquer ME, Fernández-Ramires R, Bruna FA. Braz Oral Res. See this image and copyright information in PMC. Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis Head Neck , 31 ( 2009 ) , pp. J Oral Pathol Med. 2018 Feb 20;118(4):577-586. doi: 10.1038/bjc.2017.425. JAMA Otolaryngol Head Neck Surg. Epub 2018 Mar 13. Prognostic and predictive markers for perineural and bone invasion of oral squamous cell carcinoma Jaroslav Michalek a , Svetlana Brychtova a , Richard Pink b , Zdenek Dvorak c a Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic Wang, Q. et al. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Oral squamous cell carcinoma (OSCC), the most common type of head and neck cancers, is associated with high recurrence, metastasis, low long-term … Epub 2018 Nov 8. Ries J, Agaimy A, Wehrhan F, Baran C, Bolze S, Danzer E, Frey S, Jantsch J, Möst T, Büttner-Herold M, Wickenhauser C, Kesting M, Weber M. Biomedicines. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. Epub 2018 Feb 15. Br J Cancer. National Library of Medicine Biomarkers, tumor; Mouth neoplasms; Oral cancer; Oral squamous cell carcinoma; Review; Systematic. Effects of isoprenylcysteine carboxyl methyltransferase silencing on the proliferation and apoptosis of tongue squamous cell carcinoma.